SAFETY DATA SHEETS
According to the UN GHS revision 10
SECTION 1: Identification
1.1 GHS Product identifier
| Product name |
1,3-dichloropropan-2-ol |
|---|
1.2 Other means of identification
| Product number |
- |
|---|---|
| Other names |
1,3-dichloro-1,3-dideoxyglycerol; 2-Propanol, 1,3-dichloro-; glycerol 1,3-dichlorohydrin |
1.3 Recommended use of the chemical and restrictions on use
| Identified uses |
Industrial and scientific research use. |
|---|---|
| Uses advised against |
no data available |
1.4 Supplier's details
| Company |
chemicalbook |
|---|---|
| Address |
507, building 1, Huihuang international, Shangdi 10th Street, Haidian District, Beijing |
| Telephone |
+86-10-69703845 |
1.5 Emergency phone number
| Emergency phone number |
+86-13121892008 |
|---|---|
| Service hours |
Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours). |
SECTION 2: Hazard identification
2.1 Classification of the substance or mixture
Acute toxicity - Category 3, Oral
Acute toxicity - Category 4, Dermal
Carcinogenicity, Category 1B
2.2 GHS label elements, including precautionary statements
| Pictogram(s) |
|
|---|---|
| Signal word |
Danger |
| Hazard statement(s) |
H301 Toxic if swallowed H312 Harmful in contact with skin H350 May cause cancer |
| Precautionary statement(s) | |
| Prevention |
P264 Wash ... thoroughly after handling. P270 Do not eat, drink or smoke when using this product. P280 Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/... P203 Obtain, read and follow all safety instructions before use. |
| Response |
P301+P316 IF SWALLOWED: Get emergency medical help immediately. P321 Specific treatment (see ... on this label). P330 Rinse mouth. P302+P352 IF ON SKIN: Wash with plenty of water/... P317 Get medical help. P362+P364 Take off contaminated clothing and wash it before reuse. P318 IF exposed or concerned, get medical advice. |
| Storage |
P405 Store locked up. |
| Disposal |
P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal. |
2.3 Other hazards which do not result in classification
no data available
SECTION 3: Composition/information on ingredients
3.1 Substances
| Chemical name | Common names and synonyms | CAS number | EC number | Concentration |
|---|---|---|---|---|
| 1,3-dichloropropan-2-ol | 1,3-dichloropropan-2-ol | 96-23-1 | 202-491-9 | 100% |
SECTION 4: First-aid measures
4.1 Description of necessary first-aid measures
If inhaled
Fresh air, rest. Half-upright position. Refer immediately for medical attention.
Following skin contact
Remove contaminated clothes. Rinse and then wash skin with water and soap.
Following eye contact
Rinse with plenty of water (remove contact lenses if easily possible). Refer for medical attention.
Following ingestion
Rinse mouth. Give one or two glasses of water to drink. Refer immediately for medical attention.
4.2 Most important symptoms/effects, acute and delayed
SYMPTOMS: Symptoms of exposure to this compound include hemorrhagic gastritis and pharyngitis. Other symptoms include headache, vertigo, nausea, vomiting, pulmonary edema and liver damage. ACUTE/CHRONIC HAZARDS: This compound is toxic by inhalation and ingestion. It is also harmful if absorbed through the skin. It is an irritant of the skin, eyes, mucous membranes and upper respiratory tract. When heated to decomposition it emits highly toxic fumes of carbon monoxide, carbon dioxide, hydrogen chloride gas and phosgene gas. (NTP, 1992)
4.3 Indication of immediate medical attention and special treatment needed, if necessary
Basic treatment: Establish a patent airway. Suction if necessary. Watch for signs of respiratory insufficiency and assist ventilations if necessary. Administer oxygen by nonrebreather mask at 10 to 15 L/min. Monitor for shock and treat if necessary . Monitor for pulmonary edema and treat if necessary . Anticipate seizures and treat if necessary . For eye contamination, flush eyes immediately with water. Irrigate each eye continuously with normal saline during transport . Do not use emetics. For ingestion, rinse mouth and administer 5 mL/kg up to 200 mL of water for dilution if the patient can swallow, has a strong gag reflex, and does not drool. Administer activated charcoal . Higher alcohols (> 3 carbons) and related compounds
SECTION 5: Fire-fighting measures
5.1 Suitable extinguishing media
Alcohol" foam.
5.2 Specific hazards arising from the chemical
This chemical is combustible. (NTP, 1992)
5.3 Special protective actions for fire-fighters
Use fine water spray, alcohol-resistant foam, dry powder, carbon dioxide.
SECTION 6: Accidental release measures
6.1 Personal precautions, protective equipment and emergency procedures
Personal protection: chemical protection suit including self-contained breathing apparatus. Collect leaking liquid in sealable containers.
6.2 Environmental precautions
Personal protection: chemical protection suit including self-contained breathing apparatus. Collect leaking liquid in sealable containers.
6.3 Methods and materials for containment and cleaning up
Collect and arrange disposal. Keep the chemical in suitable and closed containers for disposal. Remove all sources of ignition. Use spark-proof tools and explosion-proof equipment. Adhered or collected material should be promptly disposed of, in accordance with appropriate laws and regulations.
SECTION 7: Handling and storage
7.1 Precautions for safe handling
NO open flames. Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.
7.2 Conditions for safe storage, including any incompatibilities
Separated from strong oxidants and food and feedstuffs. Well closed.
SECTION 8: Exposure controls/personal protection
8.1 Control parameters
Occupational Exposure limit values
MAK: skin absorption (H); carcinogen category: 2
Biological limit values
no data available
8.2 Appropriate engineering controls
Ensure adequate ventilation. Handle in accordance with good industrial hygiene and safety practice. Set up emergency exits and the risk-elimination area.
8.3 Individual protection measures, such as personal protective equipment (PPE)
Eye/face protection
Wear face shield or eye protection in combination with breathing protection.
Skin protection
Protective gloves. Protective clothing.
Respiratory protection
Use ventilation, local exhaust or breathing protection.
Thermal hazards
no data available
SECTION 9: Physical and chemical properties and safety characteristics
| Physical state |
PHYSICAL DESCRIPTION: Colorless to yellow slightly viscous liquid with an ethereal odor. (NTP, 1992) |
|---|---|
| Colour |
COLORLESS, SLIGHTLY VISCOUS, LIQUID |
| Odour |
ETHEREAL ODOR |
| Melting point/freezing point |
-4°C(lit.) |
| Boiling point or initial boiling point and boiling range |
174°C |
| Flammability |
Combustible. |
| Lower and upper explosion limit/flammability limit |
no data available |
| Flash point |
74°C(lit.) |
| Auto-ignition temperature |
no data available |
| Decomposition temperature |
no data available |
| pH |
no data available |
| Kinematic viscosity |
no data available |
| Solubility |
greater than or equal to 100 mg/mL at 73° F (NTP, 1992) |
| Partition coefficient n-octanol/water |
0.78 |
| Vapour pressure |
1 mm Hg at 82.4° F ; 5 mm Hg at 126.0° F (NTP, 1992) |
| Density and/or relative density |
1.351 |
| Relative vapour density |
4.45 (NTP, 1992) (Relative to Air) |
| Particle characteristics |
no data available |
SECTION 10: Stability and reactivity
10.1 Reactivity
Decomposes on heating or on burning. This produces toxic fumes including hydrogen chloride (see ICSC 0163). Reacts with strong oxidants. Attacks powdered metals and plastic.
10.2 Chemical stability
UNSTABLE
10.3 Possibility of hazardous reactions
Flammable when exposed to heat, flame, or oxidizers.Sensitive to heat. Incompatible with oxidizers. Also incompatible with strong acids, strong reducing agents, acid chlorides and acid anhydrides. (NTP, 1992)
10.4 Conditions to avoid
no data available
10.5 Incompatible materials
no data available
10.6 Hazardous decomposition products
Dangerous; when heated to decomposition it emits highly toxic fumes of /hydrogen chloride/ and phosgene.
SECTION 11: Toxicological information
Acute toxicity
- Oral: LD50 Mouse oral 100 mg/kg
- Inhalation: no data available
- Dermal: no data available
Skin corrosion/irritation
no data available
Serious eye damage/irritation
no data available
Respiratory or skin sensitization
no data available
Germ cell mutagenicity
no data available
Carcinogenicity
no data available
Reproductive toxicity
no data available
STOT-single exposure
The substance is irritating to the eyes and respiratory tract. The substance is mildly irritating to the skin. The substance may cause effects on the liver.
STOT-repeated exposure
The substance may have effects on the liver and kidneys. This substance is possibly carcinogenic to humans.
Aspiration hazard
A harmful contamination of the air can be reached very quickly on evaporation of this substance at 20°C.
SECTION 12: Ecological information
12.1 Toxicity
- Toxicity to fish: no data available
- Toxicity to daphnia and other aquatic invertebrates: no data available
- Toxicity to algae: no data available
- Toxicity to microorganisms: no data available
12.2 Persistence and degradability
When incubated with a filtered effluent from a sanitary waste treatment plant, 1,3-dichloro-2-propanol displayed a theoretical 5 day BOD of 1%(1). 1,3-Dichloro-2-propanol reached 0%, 84%, and 86% of its theoretical BOD over 4 weeks using activated sludge inoculum(2). Pure cultures of Psuedomonas sp. degraded 1,3-dichloro-2-propanol to epichlorohydrin, 1-chloro-2,3-propylene diol, glycidol, and ultimately glycerin(3).
12.3 Bioaccumulative potential
An estimated BCF of 3 was calculated for 1,3-dichloro-2-propanol(SRC), using an estimated log Kow of 0.78(1,SRC) and a regression-derived equation(2). According to a classification scheme(3), this BCF suggests the potential for bioconcentration in aquatic organisms is low.
12.4 Mobility in soil
Using a structure estimation method based on molecular connectivity indices(1), the Koc for 1,3-dichloro-2-propanol can be estimated to be about 4(SRC). According to a classification scheme(2), this estimated Koc value suggests that 1,3-dichloro-2-propanol is expected to have very high mobility in soil.
12.5 Other adverse effects
no data available
SECTION 13: Disposal considerations
13.1 Disposal methods
Product
The material can be disposed of by removal to a licensed chemical destruction plant or by controlled incineration with flue gas scrubbing. Do not contaminate water, foodstuffs, feed or seed by storage or disposal. Do not discharge to sewer systems.
Contaminated packaging
Containers can be triply rinsed (or equivalent) and offered for recycling or reconditioning. Alternatively, the packaging can be punctured to make it unusable for other purposes and then be disposed of in a sanitary landfill. Controlled incineration with flue gas scrubbing is possible for combustible packaging materials.
SECTION 14: Transport information
14.1 UN Number
| ADR/RID: UN2750 (For reference only, please check.) | IMDG: UN2750 (For reference only, please check.) | IATA: UN2750 (For reference only, please check.) |
14.2 UN Proper Shipping Name
| ADR/RID: 1,3-DICHLOROPROPANOL-2 (For reference only, please check.) | IMDG: 1,3-DICHLOROPROPANOL-2 (For reference only, please check.) | IATA: 1,3-DICHLOROPROPANOL-2 (For reference only, please check.) |
14.3 Transport hazard class(es)
| ADR/RID: 6.1 (For reference only, please check.) | IMDG: 6.1 (For reference only, please check.) | IATA: 6.1 (For reference only, please check.) |
14.4 Packing group, if applicable
| ADR/RID: II (For reference only, please check.) | IMDG: II (For reference only, please check.) | IATA: II (For reference only, please check.) |
14.5 Environmental hazards
| ADR/RID: No | IMDG: No | IATA: No |
14.6 Special precautions for user
no data available
14.7 Transport in bulk according to IMO instruments
no data available
SECTION 15: Regulatory information
15.1 Safety, health and environmental regulations specific for the product in question
| Chemical name | Common names and synonyms | CAS number | EC number |
|---|---|---|---|
| 1,3-dichloropropan-2-ol | 1,3-dichloropropan-2-ol | 96-23-1 | 202-491-9 |
| European Inventory of Existing Commercial Chemical Substances (EINECS) | Listed. | ||
| EC Inventory | Listed. | ||
| United States Toxic Substances Control Act (TSCA) Inventory | Listed. | ||
| China Catalog of Hazardous chemicals 2015 | Listed. | ||
| New Zealand Inventory of Chemicals (NZIoC) | Listed. | ||
| Philippines Inventory of Chemicals and Chemical Substances (PICCS) | Listed. | ||
| Vietnam National Chemical Inventory | Listed. | ||
| Chinese Chemical Inventory of Existing Chemical Substances (China IECSC) | Listed. | ||
| Korea Existing Chemicals List (KECL) | Listed. | ||
SECTION 16: Other information
Information on revision
| Creation Date | July 15, 2019 |
|---|---|
| Revision Date | July 15, 2019 |
Abbreviations and acronyms
- CAS: Chemical Abstracts Service
- ADR: European Agreement concerning the International Carriage of Dangerous Goods by Road
- RID: Regulation concerning the International Carriage of Dangerous Goods by Rail
- IMDG: International Maritime Dangerous Goods
- IATA: International Air Transportation Association
- TWA: Time Weighted Average
- STEL: Short term exposure limit
- LC50: Lethal Concentration 50%
- LD50: Lethal Dose 50%
- EC50: Effective Concentration 50%
References
- IPCS - The International Chemical Safety Cards (ICSC), website: http://www.ilo.org/dyn/icsc/showcard.home
- HSDB - Hazardous Substances Data Bank, website: https://toxnet.nlm.nih.gov/newtoxnet/hsdb.htm
- IARC - International Agency for Research on Cancer, website: http://www.iarc.fr/
- eChemPortal - The Global Portal to Information on Chemical Substances by OECD, website: http://www.echemportal.org/echemportal/index?pageID=0&request_locale=en
- CAMEO Chemicals, website: http://cameochemicals.noaa.gov/search/simple
- ChemIDplus, website: http://chem.sis.nlm.nih.gov/chemidplus/chemidlite.jsp
- ERG - Emergency Response Guidebook by U.S. Department of Transportation, website: http://www.phmsa.dot.gov/hazmat/library/erg
- Germany GESTIS-database on hazard substance, website: http://www.dguv.de/ifa/gestis/gestis-stoffdatenbank/index-2.jsp
- ECHA - European Chemicals Agency, website: https://echa.europa.eu/
Any questions regarding this SDS, Please send your inquiry to sds@xixisys.com
Disclaimer: The above information is believed to be correct but does not purport to be all inclusive and shall be used only as a guide. The information in this document is based on the present state of our knowledge and is applicable to the product with regard to appropriate safety precautions. It does not represent any guarantee of the properties of the product. We as supplier shall not be held liable for any damage resulting from handling or from contact with the above product.