SAFETY DATA SHEETS
According to the UN GHS revision 10
SECTION 1: Identification
1.1 GHS Product identifier
| Product name |
2-nitroanisole |
|---|
1.2 Other means of identification
| Product number |
- |
|---|---|
| Other names |
2-NITROANISOL; 2-Nitroanisole; nitroanisole |
1.3 Recommended use of the chemical and restrictions on use
| Identified uses |
Industrial and scientific research use. |
|---|---|
| Uses advised against |
no data available |
1.4 Supplier's details
| Company |
chemicalbook |
|---|---|
| Address |
507, building 1, Huihuang international, Shangdi 10th Street, Haidian District, Beijing |
| Telephone |
+86-10-69703845 |
1.5 Emergency phone number
| Emergency phone number |
+86-13121892008 |
|---|---|
| Service hours |
Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours). |
SECTION 2: Hazard identification
2.1 Classification of the substance or mixture
Acute toxicity - Category 4, Oral
Carcinogenicity, Category 1B
2.2 GHS label elements, including precautionary statements
| Pictogram(s) |
|
|---|---|
| Signal word |
Danger |
| Hazard statement(s) |
H302 Harmful if swallowed H350 May cause cancer |
| Precautionary statement(s) | |
| Prevention |
P264 Wash ... thoroughly after handling. P270 Do not eat, drink or smoke when using this product. P203 Obtain, read and follow all safety instructions before use. P280 Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/... |
| Response |
P301+P317 IF SWALLOWED: Get medical help. P330 Rinse mouth. P318 IF exposed or concerned, get medical advice. |
| Storage |
P405 Store locked up. |
| Disposal |
P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal. |
2.3 Other hazards which do not result in classification
no data available
SECTION 3: Composition/information on ingredients
3.1 Substances
| Chemical name | Common names and synonyms | CAS number | EC number | Concentration |
|---|---|---|---|---|
| 2-nitroanisole | 2-nitroanisole | 91-23-6 | 202-052-1 | 100% |
SECTION 4: First-aid measures
4.1 Description of necessary first-aid measures
If inhaled
Fresh air, rest. Artificial respiration may be needed. Refer for medical attention.
Following skin contact
Remove contaminated clothes. Rinse and then wash skin with water and soap.
Following eye contact
First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.
Following ingestion
Rinse mouth. Give a slurry of activated charcoal in water to drink. Rest. Refer for medical attention .
4.2 Most important symptoms/effects, acute and delayed
no data available
4.3 Indication of immediate medical attention and special treatment needed, if necessary
Immediate first aid: Ensure that adequate decontamination has been carried out. If patient is not breathing, start artificial respiration, preferably with a demand-valve resuscitator, bag-valve-mask device, or pocket mask, as trained. Perform CPR as necessary. Immediately flush contaminated eyes with gently flowing water. Do not induce vomiting. If vomiting occurs, lean patient forward or place on left side (head-down position, if possible) to maintain an open airway and prevent aspiration. Keep patient quiet and maintain normal body temperature. Obtain medical attention. Aromatic hydrocarbons and related compounds
SECTION 5: Fire-fighting measures
5.1 Suitable extinguishing media
Suitable extinguishing media: Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide. Special protective equipment for fire-fighters: Wear self contained breathing apparatus for fire fighting if necessary.
5.2 Specific hazards arising from the chemical
Combustible.
5.3 Special protective actions for fire-fighters
Use carbon dioxide, foam, powder.
SECTION 6: Accidental release measures
6.1 Personal precautions, protective equipment and emergency procedures
Personal protection: chemical protection suit and filter respirator for organic gases and vapours adapted to the airborne concentration of the substance. Collect leaking and spilled liquid in sealable containers as far as possible. Absorb remaining liquid in sand or inert absorbent. Then store and dispose of according to local regulations. Do NOT let this chemical enter the environment.
6.2 Environmental precautions
Personal protection: chemical protection suit and filter respirator for organic gases and vapours adapted to the airborne concentration of the substance. Collect leaking and spilled liquid in sealable containers as far as possible. Absorb remaining liquid in sand or inert absorbent. Then store and dispose of according to local regulations. Do NOT let this chemical enter the environment.
6.3 Methods and materials for containment and cleaning up
Collect leaking liquid in sealable containers. Absorb remaining liquid in sand or inert absorbent and remove to safe place.
SECTION 7: Handling and storage
7.1 Precautions for safe handling
NO open flames. Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.
7.2 Conditions for safe storage, including any incompatibilities
Well closed.Keep container tightly closed in a dry and well-ventilated place. Containers which are opened must be carefully resealed and kept upright to prevent leakage.
SECTION 8: Exposure controls/personal protection
8.1 Control parameters
Occupational Exposure limit values
MAK: carcinogen category: 2
Biological limit values
no data available
8.2 Appropriate engineering controls
Ensure adequate ventilation. Handle in accordance with good industrial hygiene and safety practice. Set up emergency exits and the risk-elimination area.
8.3 Individual protection measures, such as personal protective equipment (PPE)
Eye/face protection
Wear safety goggles or eye protection in combination with breathing protection.
Skin protection
Protective gloves. Protective clothing.
Respiratory protection
Use ventilation, local exhaust or breathing protection.
Thermal hazards
no data available
SECTION 9: Physical and chemical properties and safety characteristics
| Physical state |
COLOURLESS-TO-YELLOW-RED LIQUID. |
|---|---|
| Colour |
Colorless to yellowish liquid |
| Odour |
no data available |
| Melting point/freezing point |
275°C(lit.) |
| Boiling point or initial boiling point and boiling range |
273°C(lit.) |
| Flammability |
Combustible. |
| Lower and upper explosion limit/flammability limit |
no data available |
| Flash point |
124°C(lit.) |
| Auto-ignition temperature |
464 deg C |
| Decomposition temperature |
no data available |
| pH |
no data available |
| Kinematic viscosity |
Liquid viscosity = 3.9768X10-3 at melting point |
| Solubility |
Miscible with ethanol, ethyl ether; soluble in carbon tetrachloride |
| Partition coefficient n-octanol/water |
log Kow = 1.73 |
| Vapour pressure |
3.6X10-3 mm Hg at 25 deg C |
| Density and/or relative density |
1.254 |
| Relative vapour density |
(air = 1): 5.29 |
| Particle characteristics |
no data available |
SECTION 10: Stability and reactivity
10.1 Reactivity
On combustion, forms toxic and corrosive fumes.
10.2 Chemical stability
no data available
10.3 Possibility of hazardous reactions
The vapour is heavier than air.
10.4 Conditions to avoid
no data available
10.5 Incompatible materials
no data available
10.6 Hazardous decomposition products
When heated to decomposition it emits toxic fumes of /nitrogen oxide/.
SECTION 11: Toxicological information
Acute toxicity
- Oral: LD50 Rat oral 1980 mg/kg
- Inhalation: no data available
- Dermal: no data available
Skin corrosion/irritation
no data available
Serious eye damage/irritation
no data available
Respiratory or skin sensitization
no data available
Germ cell mutagenicity
no data available
Carcinogenicity
Evaluation: There is inadequate evidence in humans for the carcinogenicity of 2-nitroanisole. There is sufficient evidence in experimental animals for the carcinogenicity of 2-nitroanisole. Overall evaluation: 2-Nitroanisole is possibly carcinogenic to humans (Group 2B).
Reproductive toxicity
no data available
STOT-single exposure
Exposure at high levels could cause formation of methaemoglobin. The effects may be delayed. Medical observation is indicated.
STOT-repeated exposure
The substance defats the skin, which may cause dryness or cracking. This substance is possibly carcinogenic to humans. The substance may have effects on the blood. This may result in anaemia.
Aspiration hazard
A harmful concentration of airborne particles can be reached quickly on spraying.
SECTION 12: Ecological information
12.1 Toxicity
- Toxicity to fish: LC50; Species: Pimephales promelas (Fathead minnow); Conditions: static; Concentration: 216.1 mg/L/96 hr
- Toxicity to daphnia and other aquatic invertebrates: EC50; Species: Daphnia magna (Water flea); Conditions: freshwater, renewal, 25 deg C, pH >7.0; Concentration: 65000 ug/L for 24 hr; Effect: behavior, equilibrium /formulation
- Toxicity to algae: EC50; Species: Scenedesmus subspicatus (algae); Conditions: OECD Guideline 201; Concentration: 48.6 mg/L/72 hr; Endpoint: growth rate
- Toxicity to microorganisms: no data available
12.2 Persistence and degradability
AEROBIC: 2-Nitroanisole is considered non-biodegradable(1). o-Nitroanisole, present at 100 mg/L, reached 0% of its theoretical BOD in 2 weeks using an activated sludge inoculum at 30 mg/L in the Japanese MITI test(2). Greater than 64 days were required to degrade 2-nitroanisole by a soil microflora inoculum from a Niagara silt loam in a mineral salts medium(3).
12.3 Bioaccumulative potential
Measured BCF ranges of 1.4-2.3 and 2.7-5.2 at test chemical concentrations of 50 and 5 ppb, respectively, were reported in fish for 2-nitroanisole using carp (Cyprinus carpio) which were exposed over an 8-week period(1). According to a classification scheme(2), this BCF suggests the potential for bioconcentration in aquatic organisms is low(SRC).
12.4 Mobility in soil
The Koc of 2-nitroanisole is estimated as 140(SRC), using a log Kow of 1.73(1) and a regression-derived equation(2). According to a classification scheme(3), this estimated Koc value suggests that 2-nitroanisole is expected to have high mobility in soil.
12.5 Other adverse effects
no data available
SECTION 13: Disposal considerations
13.1 Disposal methods
Product
The material can be disposed of by removal to a licensed chemical destruction plant or by controlled incineration with flue gas scrubbing. Do not contaminate water, foodstuffs, feed or seed by storage or disposal. Do not discharge to sewer systems.
Contaminated packaging
Containers can be triply rinsed (or equivalent) and offered for recycling or reconditioning. Alternatively, the packaging can be punctured to make it unusable for other purposes and then be disposed of in a sanitary landfill. Controlled incineration with flue gas scrubbing is possible for combustible packaging materials.
SECTION 14: Transport information
14.1 UN Number
| ADR/RID: UN2730 (For reference only, please check.) | IMDG: UN2730 (For reference only, please check.) | IATA: UN2730 (For reference only, please check.) |
14.2 UN Proper Shipping Name
| ADR/RID: NITROANISOLES, LIQUID (For reference only, please check.) | IMDG: NITROANISOLES, LIQUID (For reference only, please check.) | IATA: NITROANISOLES, LIQUID (For reference only, please check.) |
14.3 Transport hazard class(es)
| ADR/RID: 6.1 (For reference only, please check.) | IMDG: 6.1 (For reference only, please check.) | IATA: 6.1 (For reference only, please check.) |
14.4 Packing group, if applicable
| ADR/RID: III (For reference only, please check.) | IMDG: III (For reference only, please check.) | IATA: III (For reference only, please check.) |
14.5 Environmental hazards
| ADR/RID: No | IMDG: No | IATA: No |
14.6 Special precautions for user
no data available
14.7 Transport in bulk according to IMO instruments
no data available
SECTION 15: Regulatory information
15.1 Safety, health and environmental regulations specific for the product in question
| Chemical name | Common names and synonyms | CAS number | EC number |
|---|---|---|---|
| 2-nitroanisole | 2-nitroanisole | 91-23-6 | 202-052-1 |
| European Inventory of Existing Commercial Chemical Substances (EINECS) | Listed. | ||
| EC Inventory | Listed. | ||
| United States Toxic Substances Control Act (TSCA) Inventory | Listed. | ||
| China Catalog of Hazardous chemicals 2015 | Listed. | ||
| New Zealand Inventory of Chemicals (NZIoC) | Listed. | ||
| Philippines Inventory of Chemicals and Chemical Substances (PICCS) | Listed. | ||
| Vietnam National Chemical Inventory | Listed. | ||
| Chinese Chemical Inventory of Existing Chemical Substances (China IECSC) | Listed. | ||
| Korea Existing Chemicals List (KECL) | Listed. | ||
SECTION 16: Other information
Information on revision
| Creation Date | July 15, 2019 |
|---|---|
| Revision Date | July 15, 2019 |
Abbreviations and acronyms
- CAS: Chemical Abstracts Service
- ADR: European Agreement concerning the International Carriage of Dangerous Goods by Road
- RID: Regulation concerning the International Carriage of Dangerous Goods by Rail
- IMDG: International Maritime Dangerous Goods
- IATA: International Air Transportation Association
- TWA: Time Weighted Average
- STEL: Short term exposure limit
- LC50: Lethal Concentration 50%
- LD50: Lethal Dose 50%
- EC50: Effective Concentration 50%
References
- IPCS - The International Chemical Safety Cards (ICSC), website: http://www.ilo.org/dyn/icsc/showcard.home
- HSDB - Hazardous Substances Data Bank, website: https://toxnet.nlm.nih.gov/newtoxnet/hsdb.htm
- IARC - International Agency for Research on Cancer, website: http://www.iarc.fr/
- eChemPortal - The Global Portal to Information on Chemical Substances by OECD, website: http://www.echemportal.org/echemportal/index?pageID=0&request_locale=en
- CAMEO Chemicals, website: http://cameochemicals.noaa.gov/search/simple
- ChemIDplus, website: http://chem.sis.nlm.nih.gov/chemidplus/chemidlite.jsp
- ERG - Emergency Response Guidebook by U.S. Department of Transportation, website: http://www.phmsa.dot.gov/hazmat/library/erg
- Germany GESTIS-database on hazard substance, website: http://www.dguv.de/ifa/gestis/gestis-stoffdatenbank/index-2.jsp
- ECHA - European Chemicals Agency, website: https://echa.europa.eu/
Other Information
Do NOT take working clothes home.Depending on the degree of exposure, periodic medical examination is suggested.Specific treatment is necessary in case of poisoning with this substance; the appropriate means with instructions must be available.
Any questions regarding this SDS, Please send your inquiry to sds@xixisys.com
Disclaimer: The above information is believed to be correct but does not purport to be all inclusive and shall be used only as a guide. The information in this document is based on the present state of our knowledge and is applicable to the product with regard to appropriate safety precautions. It does not represent any guarantee of the properties of the product. We as supplier shall not be held liable for any damage resulting from handling or from contact with the above product.