SAFETY DATA SHEETS
According to the UN GHS revision 10
SECTION 1: Identification
1.1 GHS Product identifier
| Product name |
Phthalic anhydride |
|---|
1.2 Other means of identification
| Product number |
- |
|---|---|
| Other names |
1,3-DIHYDRO-IMIDAZOL-2-ONE; 4-imidazolin-2-one; 1H-imidazol-2(3H)-one |
1.3 Recommended use of the chemical and restrictions on use
| Identified uses |
Industrial and scientific research use. |
|---|---|
| Uses advised against |
no data available |
1.4 Supplier's details
| Company |
chemicalbook |
|---|---|
| Address |
507, building 1, Huihuang international, Shangdi 10th Street, Haidian District, Beijing |
| Telephone |
+86-10-69703845 |
1.5 Emergency phone number
| Emergency phone number |
+86-13121892008 |
|---|---|
| Service hours |
Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours). |
SECTION 2: Hazard identification
2.1 Classification of the substance or mixture
Acute toxicity - Category 4, Oral
Skin irritation, Category 2
Serious eye damage, Category 1
Skin sensitization, Category 1
Specific target organ toxicity – single exposure, Category 3
Respiratory sensitization, Category 1
2.2 GHS label elements, including precautionary statements
| Pictogram(s) |
|
|---|---|
| Signal word |
Danger |
| Hazard statement(s) |
H302 Harmful if swallowed H315 Causes skin irritation H318 Causes serious eye damage H317 May cause an allergic skin reaction H335 May cause respiratory irritation H334 May cause allergy or asthma symptoms or breathing difficulties if inhaled |
| Precautionary statement(s) | |
| Prevention |
P264 Wash ... thoroughly after handling. P270 Do not eat, drink or smoke when using this product. P280 Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/... P261 Avoid breathing dust/fume/gas/mist/vapours/spray. P272 Contaminated work clothing should not be allowed out of the workplace. P271 Use only outdoors or in a well-ventilated area. P284 [In case of inadequate ventilation] wear respiratory protection. |
| Response |
P301+P317 IF SWALLOWED: Get medical help. P330 Rinse mouth. P302+P352 IF ON SKIN: Wash with plenty of water/... P321 Specific treatment (see ... on this label). P332+P317 If skin irritation occurs: Get medical help. P362+P364 Take off contaminated clothing and wash it before reuse. P305+P354+P338 IF IN EYES: Immediately rinse with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P317 Get medical help. P333+P317 If skin irritation or rash occurs: Get medical help. P304+P340 IF INHALED: Remove person to fresh air and keep comfortable for breathing. P319 Get medical help if you feel unwell. P342+P316 If experiencing respiratory symptoms: Get emergency medical help immediately. |
| Storage |
P403+P233 Store in a well-ventilated place. Keep container tightly closed. P405 Store locked up. |
| Disposal |
P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal. |
2.3 Other hazards which do not result in classification
no data available
SECTION 3: Composition/information on ingredients
3.1 Substances
| Chemical name | Common names and synonyms | CAS number | EC number | Concentration |
|---|---|---|---|---|
| Phthalic anhydride | Phthalic anhydride | 85-44-9 | 201-607-5 | 100% |
SECTION 4: First-aid measures
4.1 Description of necessary first-aid measures
If inhaled
Fresh air, rest. Half-upright position. Refer for medical attention.
Following skin contact
Remove contaminated clothes. Rinse and then wash skin with water and soap. Refer for medical attention .
Following eye contact
First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.
Following ingestion
Rinse mouth. Do NOT induce vomiting. Give one or two glasses of water to drink. Refer for medical attention .
4.2 Most important symptoms/effects, acute and delayed
Solid irritates skin and eyes, causing coughing and sneezing. Liquid causes severe thermal burns. (USCG, 1999)
4.3 Indication of immediate medical attention and special treatment needed, if necessary
First aid: Inhalation - Fresh air, rest. Half-upright position. Refer for medical attention. Skin - Remove contaminated clothes. Rinse and then wash skin with water and soap. Refer for medical attention. Eyes - First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then take to a doctor. Ingestion - Rinse mouth. Do NOT induce vomiting. Give plenty of water to drink. Refer for medical attention.
SECTION 5: Fire-fighting measures
5.1 Suitable extinguishing media
Suitable extinguishing media: Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.
5.2 Specific hazards arising from the chemical
Excerpt from ERG Guide 156 [Substances - Toxic and/or Corrosive (Combustible / Water-Sensitive)]: Combustible material: may burn but does not ignite readily. Substance will react with water (some violently) releasing flammable, toxic or corrosive gases and runoff. When heated, vapors may form explosive mixtures with air: indoors, outdoors and sewers explosion hazards. Most vapors are heavier than air. They will spread along ground and collect in low or confined areas (sewers, basements, tanks). Vapors may travel to source of ignition and flash back. Contact with metals may evolve flammable hydrogen gas. Containers may explode when heated or if contaminated with water. (ERG, 2016)
5.3 Special protective actions for fire-fighters
Use water spray, foam, dry powder, carbon dioxide.
SECTION 6: Accidental release measures
6.1 Personal precautions, protective equipment and emergency procedures
Personal protection: chemical protection suit including self-contained breathing apparatus. Sweep spilled substance into covered containers. If appropriate, moisten first to prevent dusting. Carefully collect remainder. Then store and dispose of according to local regulations.
6.2 Environmental precautions
Personal protection: chemical protection suit including self-contained breathing apparatus. Sweep spilled substance into covered containers. If appropriate, moisten first to prevent dusting. Carefully collect remainder. Then store and dispose of according to local regulations.
6.3 Methods and materials for containment and cleaning up
Personal precautions, protective equipment and emergency procedures: Use personal protective equipment. Avoid dust formation. Avoid breathing vapors, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas. Avoid breathing dust.
SECTION 7: Handling and storage
7.1 Precautions for safe handling
NO open flames. Closed system, dust explosion-proof electrical equipment and lighting. Prevent deposition of dust. Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.
7.2 Conditions for safe storage, including any incompatibilities
Separated from combustible substances, reducing agents, strong oxidants, strong bases, strong acids and food and feedstuffs. See Chemical Dangers. Ventilation along the floor. Dry. Well closed.Chemical stability: Stable under recommended storage conditions.
SECTION 8: Exposure controls/personal protection
8.1 Control parameters
Occupational Exposure limit values
TLV: 0.002 mg/m3, as TWA; 0.005 mg/m3 as STEL; (skin); (SEN); A4 (not classifiable as a human carcinogen).MAK: sensitization of respiratory tract (SA)
Biological limit values
no data available
8.2 Appropriate engineering controls
Ensure adequate ventilation. Handle in accordance with good industrial hygiene and safety practice. Set up emergency exits and the risk-elimination area.
8.3 Individual protection measures, such as personal protective equipment (PPE)
Eye/face protection
Wear safety goggles or eye protection in combination with breathing protection.
Skin protection
Protective gloves. Protective clothing.
Respiratory protection
Use local exhaust or breathing protection.
Thermal hazards
no data available
SECTION 9: Physical and chemical properties and safety characteristics
| Physical state |
Solid. Crystalline. |
|---|---|
| Colour |
Colourless. |
| Odour |
Mild |
| Melting point/freezing point |
131.6 °C. |
| Boiling point or initial boiling point and boiling range |
284.5 °C. Atm. press.:1 013 hPa. |
| Flammability |
Combustible Solid |
| Lower and upper explosion limit/flammability limit |
Lower flammable limit: 1.7% by volume; Upper flammable limit: 10.5% by volume |
| Flash point |
152 °C. |
| Auto-ignition temperature |
580 °C. |
| Decomposition temperature |
no data available |
| pH |
no data available |
| Kinematic viscosity |
dynamic viscosity (in mPa s) = 1.125. Temperature:155.0°C. Remarks:Reference :Beilstein, 2003.;dynamic viscosity (in mPa s) = 0.875. Temperature:180.0°C. Remarks:Reference: Beilstein, 2003.;dynamic viscosity (in mPa s) = 1.19. Temperature:132.0°C. Remarks:Reference: Kirk-Othmer, 2008. |
| Solubility |
6.4 g / L (20 °C) |
| Partition coefficient n-octanol/water |
log Pow = 1.6. |
| Vapour pressure |
0.001 hPa. Temperature:26.6 °C. |
| Density and/or relative density |
1.53 g/cm3. Temperature:20 °C. |
| Relative vapour density |
5.1 (vs air) |
| Particle characteristics |
no data available |
SECTION 10: Stability and reactivity
10.1 Reactivity
Decomposes on contact with hot water. This produces phthalic acid. Reacts with strong oxidants, strong acids, strong bases and reducing agents. Reacts violently with copper oxide and sodium nitrite on heating. This generates explosion hazard. Attacks many metals in the presence of water.
10.2 Chemical stability
no data available
10.3 Possibility of hazardous reactions
Combustible solidDust explosion possible if in powder or granular form, mixed with air.PHTHALIC ANHYDRIDE reacts exothermically with water. The reactions are sometimes slow, but can become violent when local heating accelerates their rate. Acids accelerate the reaction with water. Incompatible with acids, strong oxidizing agents, alcohols, amines, and bases. Undergoes exothmeric nitration with fuming nitric acid-sulfuric acid and may give mixtures of the potentially explosive phthaloyl nitrates or nitrites or their nitro derivatives [Chem. & Ind. 20:790. 1972]. Phthalic anhydride reacts violently with CuO at elevated temperatures [Park, Chang-Man, Richard J. Sheehan. "Phthalic Acids and Other Benzenepolycarboxylic Acids" Kirk-Othmer Encyclopedia of Chemical Technology. John Wiley & Sons, Inc. 2005]. Mixtures of phthalic anhydride and anhydrous CO2 explode violently if heated [Leaflet No. 5, Inst. of Chem., London, 1940].
10.4 Conditions to avoid
no data available
10.5 Incompatible materials
Strong oxidizers, water [Note: Converted to phthalic acid in hot water].
10.6 Hazardous decomposition products
Phthalic anhydride hydrolyzes rapidly in the presence of water forming phthalic acid. Half-life for phthalic anhydride was 30.5 seconds at pH 7.24. At pH 6.8 the half-life of phthtalic anhydride in water was prolonged to 61 seconds.
SECTION 11: Toxicological information
Acute toxicity
- Oral: LD50 - rat (male) - 1 530 mg/kg bw.
- Inhalation: LC50 - rat (male/female) - > 2.14 mg/L air (analytical).
- Dermal: LD50 - rabbit - > 10 000 mg/kg bw.
Skin corrosion/irritation
no data available
Serious eye damage/irritation
no data available
Respiratory or skin sensitization
no data available
Germ cell mutagenicity
no data available
Carcinogenicity
A4; Not classifiable as a human carcinogen.
Reproductive toxicity
No studies regarding reproductive or developmental effects in humans were available. Phthalic anhydride was reported to be teratogenic in mice following intraperitoneal injection. Decreased spermatozoa motility time was reported in one study in which male rats were exposed via inhalation.
STOT-single exposure
The substance is severely irritating to the eyes, skin and respiratory tract.
STOT-repeated exposure
Repeated or prolonged contact may cause skin sensitization. Repeated or prolonged inhalation may cause asthma. See Notes.
Aspiration hazard
A harmful concentration of airborne particles can be reached quickly when dispersed, especially if powdered.
SECTION 12: Ecological information
12.1 Toxicity
- Toxicity to fish: LC50 - Danio rerio (previous name: Brachydanio rerio) - 560 mg/L - 7 d.
- Toxicity to daphnia and other aquatic invertebrates: EC50 - Daphnia magna - > 640 mg/L - 48 h.
- Toxicity to algae: EC0 - Desmodesmus subspicatus (previous name: Scenedesmus subspicatus) - >= 100 mg/L - 72 h.
- Toxicity to microorganisms: EC50 - activated sludge - > 1 000 mg/L - 3 h. Remarks:Respiration rate.
12.2 Persistence and degradability
AEROBIC: Based on the available experimental biodegradation test results, phthalic anhydride can be classified as readily biodegradable(1). However, phthalic anhydride hydrolyzes rapidly in water with a half-life of about 25 minutes or less at 25 deg C(1,2), and biodegradation test results may be reflective of biodegradation of phthalic acid which is the hydrolysis product of phthalic anhydride(1,2). Phthalic anhydride, present at 100 mg/L, reached 85.2% of its theoretical BOD in 2 weeks using an activated sludge inoculum at 30 mg/L in the Japanese MITI test(3); it was noted that the phthalic anhydride had been hydrolyzed to phthalic acid(3). Using OECD Method 301D (closed bottle test) and a domestic sewage inoculum, phthalic anhydride reached 71% of theoretical BOD after 30 days(1). Phthalic anhydride was reported to have a 5 day theoretical oxygen demand of 73.46% using 0.5 ppm concentration with a sewage inoculum(4). Theoretical BOD was reported to be 44-78% as a result of incubation of 1-4 ppm with sewage inoculum(5). Reported degradation of an initial concentration of 2 ppm phthalic anhydride was approximately 22% after incubation with sewage (standard dilution method) and 18% (seawater dilution method) for 5 days(6). Mineralization of 33% of an initial concentration of 9 ppm phthalic anhyride incubated with activated sludge for 24 hrs was reported based on chemical oxygen demand(7). Phthalic anhydride degradation using an acclimated activated sludge gave a 33% chemical oxygen demand and 88% total organic carbon in 24 hours(8).
12.3 Bioaccumulative potential
An estimated BCF of 5 was calculated in fish for phthalic anhydride(SRC), using a log Kow of 1.60(1) and a regression-derived equation(2). According to a classification scheme(3), this BCF suggests the potential for bioconcentration in aquatic organisms is low(SRC). Phthalic anhydride did not bioconcentrate in Gambusia (mosquito fish)(4). Phthalic anhydride has a reported BCF of 4,053 in Oedogonium (alga) but did not bioconcentrate in Daphnia (water flea) or Physa (snail)(4). Phthalic anhydride hydrolyzes rapidly in water with a half-life of about 25 minutes or less at 25 deg C(1,5) which suggests that bioconcentration in fish may not be an important fate process(SRC).
12.4 Mobility in soil
Using a structure estimation method based on molecular connectivity indices(1), the Koc of phthalic anhydride can be estimated to be 10(SRC). According to a classification scheme(2), this estimated Koc value suggests that phthalic anhydride is expected to have very high mobility in soil. Phthalic anhydride hydrolyzes rapidly in water with a half-life of about 25 minutes or less at 25 deg C(3,4) which suggests that leaching may not be an important fate process(SRC).
12.5 Other adverse effects
no data available
SECTION 13: Disposal considerations
13.1 Disposal methods
Product
The material can be disposed of by removal to a licensed chemical destruction plant or by controlled incineration with flue gas scrubbing. Do not contaminate water, foodstuffs, feed or seed by storage or disposal. Do not discharge to sewer systems.
Contaminated packaging
Containers can be triply rinsed (or equivalent) and offered for recycling or reconditioning. Alternatively, the packaging can be punctured to make it unusable for other purposes and then be disposed of in a sanitary landfill. Controlled incineration with flue gas scrubbing is possible for combustible packaging materials.
SECTION 14: Transport information
14.1 UN Number
| ADR/RID: UN3256 (For reference only, please check.) | IMDG: UN3256 (For reference only, please check.) | IATA: UN3256 (For reference only, please check.) |
14.2 UN Proper Shipping Name
| ADR/RID: ELEVATED TEMPERATURE LIQUID, FLAMMABLE, N.O.S. with flash point above 60 °C, at or above its flash point (For reference only, please check.) | IMDG: ELEVATED TEMPERATURE LIQUID, FLAMMABLE, N.O.S. with flash point above 60 °C, at or above its flash point (For reference only, please check.) | IATA: ELEVATED TEMPERATURE LIQUID, FLAMMABLE, N.O.S. with flash point above 60 °C, at or above its flash point (For reference only, please check.) |
14.3 Transport hazard class(es)
| ADR/RID: 3 (For reference only, please check.) | IMDG: 3 (For reference only, please check.) | IATA: 3 (For reference only, please check.) |
14.4 Packing group, if applicable
| ADR/RID: III (For reference only, please check.) | IMDG: III (For reference only, please check.) | IATA: III (For reference only, please check.) |
14.5 Environmental hazards
| ADR/RID: No | IMDG: No | IATA: No |
14.6 Special precautions for user
no data available
14.7 Transport in bulk according to IMO instruments
no data available
SECTION 15: Regulatory information
15.1 Safety, health and environmental regulations specific for the product in question
| Chemical name | Common names and synonyms | CAS number | EC number |
|---|---|---|---|
| Phthalic anhydride | Phthalic anhydride | 85-44-9 | 201-607-5 |
| European Inventory of Existing Commercial Chemical Substances (EINECS) | Listed. | ||
| EC Inventory | Listed. | ||
| United States Toxic Substances Control Act (TSCA) Inventory | Listed. | ||
| China Catalog of Hazardous chemicals 2015 | Listed. | ||
| New Zealand Inventory of Chemicals (NZIoC) | Listed. | ||
| Philippines Inventory of Chemicals and Chemical Substances (PICCS) | Listed. | ||
| Vietnam National Chemical Inventory | Listed. | ||
| Chinese Chemical Inventory of Existing Chemical Substances (China IECSC) | Listed. | ||
| Korea Existing Chemicals List (KECL) | Listed. | ||
SECTION 16: Other information
Information on revision
| Creation Date | July 15, 2019 |
|---|---|
| Revision Date | July 15, 2019 |
Abbreviations and acronyms
- CAS: Chemical Abstracts Service
- ADR: European Agreement concerning the International Carriage of Dangerous Goods by Road
- RID: Regulation concerning the International Carriage of Dangerous Goods by Rail
- IMDG: International Maritime Dangerous Goods
- IATA: International Air Transportation Association
- TWA: Time Weighted Average
- STEL: Short term exposure limit
- LC50: Lethal Concentration 50%
- LD50: Lethal Dose 50%
- EC50: Effective Concentration 50%
References
- IPCS - The International Chemical Safety Cards (ICSC), website: http://www.ilo.org/dyn/icsc/showcard.home
- HSDB - Hazardous Substances Data Bank, website: https://toxnet.nlm.nih.gov/newtoxnet/hsdb.htm
- IARC - International Agency for Research on Cancer, website: http://www.iarc.fr/
- eChemPortal - The Global Portal to Information on Chemical Substances by OECD, website: http://www.echemportal.org/echemportal/index?pageID=0&request_locale=en
- CAMEO Chemicals, website: http://cameochemicals.noaa.gov/search/simple
- ChemIDplus, website: http://chem.sis.nlm.nih.gov/chemidplus/chemidlite.jsp
- ERG - Emergency Response Guidebook by U.S. Department of Transportation, website: http://www.phmsa.dot.gov/hazmat/library/erg
- Germany GESTIS-database on hazard substance, website: http://www.dguv.de/ifa/gestis/gestis-stoffdatenbank/index-2.jsp
- ECHA - European Chemicals Agency, website: https://echa.europa.eu/
Other Information
The substance may be transported in molten state.The symptoms of asthma often do not become manifest until a few hours have passed and they are aggravated by physical effort.Rest and medical observation are therefore essential.Anyone who has shown symptoms of asthma due to this substance should avoid all further contact with this substance.For materials containing more than 0.05% of maleic anhydride the UN number is 2214, hazard class 8, packaging group III.Do NOT take working clothes home.
Any questions regarding this SDS, Please send your inquiry to sds@xixisys.com
Disclaimer: The above information is believed to be correct but does not purport to be all inclusive and shall be used only as a guide. The information in this document is based on the present state of our knowledge and is applicable to the product with regard to appropriate safety precautions. It does not represent any guarantee of the properties of the product. We as supplier shall not be held liable for any damage resulting from handling or from contact with the above product.