SAFETY DATA SHEETS
According to the UN GHS revision 10
SECTION 1: Identification
1.1 GHS Product identifier
| Product name |
Acetonitrile |
|---|
1.2 Other means of identification
| Product number |
- |
|---|---|
| Other names |
Acetonitrile; CH3CN; ACN |
1.3 Recommended use of the chemical and restrictions on use
| Identified uses |
Industrial and scientific research use. |
|---|---|
| Uses advised against |
no data available |
1.4 Supplier's details
| Company |
chemicalbook |
|---|---|
| Address |
507, building 1, Huihuang international, Shangdi 10th Street, Haidian District, Beijing |
| Telephone |
+86-10-69703845 |
1.5 Emergency phone number
| Emergency phone number |
+86-13121892008 |
|---|---|
| Service hours |
Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours). |
SECTION 2: Hazard identification
2.1 Classification of the substance or mixture
Flammable liquids, Category 2
Acute toxicity - Category 4, Oral
Acute toxicity - Category 4, Dermal
Eye irritation, Category 2
Acute toxicity - Category 4, Inhalation
2.2 GHS label elements, including precautionary statements
| Pictogram(s) |
|
|---|---|
| Signal word |
Danger |
| Hazard statement(s) |
H225 Highly flammable liquid and vapour H302 Harmful if swallowed H312 Harmful in contact with skin H319 Causes serious eye irritation H332 Harmful if inhaled |
| Precautionary statement(s) | |
| Prevention |
P210 Keep away from heat, hot surfaces, sparks, open flames and other ignition sources. No smoking. P233 Keep container tightly closed. P240 Ground and bond container and receiving equipment. P241 Use explosion-proof [electrical/ventilating/lighting/...] equipment. P242 Use non-sparking tools. P243 Take action to prevent static discharges. P280 Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/... P264 Wash ... thoroughly after handling. P270 Do not eat, drink or smoke when using this product. P261 Avoid breathing dust/fume/gas/mist/vapours/spray. P271 Use only outdoors or in a well-ventilated area. |
| Response |
P303+P361+P353 IF ON SKIN (or hair): Take off immediately all contaminated clothing. Rinse affected areas with water [or shower]. P370+P378 In case of fire: Use ... to extinguish. P301+P317 IF SWALLOWED: Get medical help. P330 Rinse mouth. P302+P352 IF ON SKIN: Wash with plenty of water/... P317 Get medical help. P321 Specific treatment (see ... on this label). P362+P364 Take off contaminated clothing and wash it before reuse. P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P304+P340 IF INHALED: Remove person to fresh air and keep comfortable for breathing. |
| Storage |
P403+P235 Store in a well-ventilated place. Keep cool. |
| Disposal |
P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal. |
2.3 Other hazards which do not result in classification
no data available
SECTION 3: Composition/information on ingredients
3.1 Substances
| Chemical name | Common names and synonyms | CAS number | EC number | Concentration |
|---|---|---|---|---|
| Acetonitrile | Acetonitrile | 75-05-8 | 200-835-2 | 100% |
SECTION 4: First-aid measures
4.1 Description of necessary first-aid measures
If inhaled
Fresh air, rest. Artificial respiration may be needed. No mouth-to-mouth artificial respiration. Refer immediately for medical attention. See Notes.
Following skin contact
Remove contaminated clothes. Rinse skin with plenty of water or shower. Refer for medical attention .
Following eye contact
Rinse with plenty of water (remove contact lenses if easily possible). Refer immediately for medical attention.
Following ingestion
Rinse mouth. Give one or two glasses of water to drink. Do NOT induce vomiting. Refer immediately for medical attention.
4.2 Most important symptoms/effects, acute and delayed
Exposure to 160 ppm for 4 hours causes flushing of the face and a feeling of constriction in the chest; 500 ppm for brief periods is irritating to the nose and throat. Severe exposures cause irritability, skin eruptions, confusion, delirium, convulsions, paralysis, and death due to central nervous system depression. (USCG, 1999)
4.3 Indication of immediate medical attention and special treatment needed, if necessary
Immediate first aid: Ensure that adequate decontamination has been carried out. If patient is not breathing, start artificial respiration, preferably with a demand-valve resuscitator, bog-valve-mask device, or pocket mask, as trained. Perform CPR if necessary. Immediately flush contaminated eyes with gently flowing water. Do not induce vomiting. If vomiting occurs, lean patient forward or place on left side (head-down position, if possible) to maintain an open airway and prevent aspiration. Keep patient quiet and maintain normal body temperature. Obtain medical attention. Cyanide and related compounds
SECTION 5: Fire-fighting measures
5.1 Suitable extinguishing media
Foam, carbon dioxide, dry chemical
5.2 Specific hazards arising from the chemical
Special Hazards of Combustion Products: Toxic vapors are generated when heated Behavior in Fire: Vapor heavier than air and may travel a considerable distance to a source of ignition and flash back. (USCG, 1999)
5.3 Special protective actions for fire-fighters
Use powder, foam, carbon dioxide. Water may be ineffective. In case of fire: keep drums, etc., cool by spraying with water.
SECTION 6: Accidental release measures
6.1 Personal precautions, protective equipment and emergency procedures
Consult an expert! Personal protection: complete protective clothing including self-contained breathing apparatus. Ventilation. Remove all ignition sources. Collect leaking and spilled liquid in sealable containers as far as possible. Absorb remaining liquid in dry sand or inert absorbent. Then store and dispose of according to local regulations.
6.2 Environmental precautions
Consult an expert! Personal protection: complete protective clothing including self-contained breathing apparatus. Ventilation. Remove all ignition sources. Collect leaking and spilled liquid in sealable containers as far as possible. Absorb remaining liquid in dry sand or inert absorbent. Then store and dispose of according to local regulations.
6.3 Methods and materials for containment and cleaning up
ACCIDENTAL RELEASE MEASURES. Personal precautions, protective equipment and emergency procedures: Use personal protective equipment. Avoid breathing vapours, mist or gas. Ensure adequate ventilation. Remove all sources of ignition. Evacuate personnel to safe areas. Beware of vapours accumulating to form explosive concentrations. Vapours can accumulate in low areas.; Environmental precautions: Prevent further leakage or spillage if safe to do so. Do not let product enter drains.; Methods and materials for containment and cleaning up: Contain spillage, and then collect with an electrically protected vacuum cleaner or by wet-brushing and place in container for disposal according to local regulations.
SECTION 7: Handling and storage
7.1 Precautions for safe handling
NO open flames, NO sparks and NO smoking. NO contact with hot surfaces or strong oxidizing agents. Closed system, ventilation, explosion-proof electrical equipment and lighting. Do NOT use compressed air for filling, discharging, or handling. Use non-sparking handtools. Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.
7.2 Conditions for safe storage, including any incompatibilities
Fireproof. Keep in a well-ventilated room. Separated from acids, bases, strong oxidants and food and feedstuffs. Well closed.Protect containers against physical damage. Outdoor or detached storage is preferable. Separate from any sources of ignition and combustible materials. Storage room should be well-ventilated.
SECTION 8: Exposure controls/personal protection
8.1 Control parameters
Occupational Exposure limit values
TLV: 20 ppm as TWA; (skin); A4 (not classifiable as a human carcinogen).MAK: 17 mg/m3, 10 ppm; peak limitation category: II(2); skin absorption (H); pregnancy risk group: C.EU-OEL: 70 mg/m3, 40 ppm as TWA; (skin)
Biological limit values
no data available
8.2 Appropriate engineering controls
Ensure adequate ventilation. Handle in accordance with good industrial hygiene and safety practice. Set up emergency exits and the risk-elimination area.
8.3 Individual protection measures, such as personal protective equipment (PPE)
Eye/face protection
Wear face shield or eye protection in combination with breathing protection.
Skin protection
Protective gloves. Protective clothing.
Respiratory protection
Use ventilation, local exhaust or breathing protection.
Thermal hazards
no data available
SECTION 9: Physical and chemical properties and safety characteristics
| Physical state |
Liquid. |
|---|---|
| Colour |
Clear, colorless. |
| Odour |
Aromatic odor |
| Melting point/freezing point |
-45.7 °C. |
| Boiling point or initial boiling point and boiling range |
81.6 °C. Atm. press.:1 013.25 hPa. |
| Flammability |
Class IB Flammable Liquid: Fl.P. below 73°F and BP at or above 100°F. |
| Lower and upper explosion limit/flammability limit |
Lower flammable limit: 3.0%; Upper flammable limit: 16.0% |
| Flash point |
12.8 °C. |
| Auto-ignition temperature |
524 °C. |
| Decomposition temperature |
no data available |
| pH |
no data available |
| Kinematic viscosity |
0.35 cP at 20 deg C |
| Solubility |
Miscible with water |
| Partition coefficient n-octanol/water |
log Pow = -0.34. |
| Vapour pressure |
94.51 hPa. Temperature:20 °C. Remarks:Upper value: 98.64 hPa. |
| Density and/or relative density |
0.79. Temperature:20 °C. |
| Relative vapour density |
1.41 (vs air) |
| Particle characteristics |
no data available |
SECTION 10: Stability and reactivity
10.1 Reactivity
Decomposes on heating or on burning and on contact with hot surfaces. This produces toxic fumes including hydrogen cyanide and nitrogen oxides. Reacts violently with strong oxidants. This generates fire and explosion hazard. Reacts with acids and bases. This produces toxic and flammable hydrogen cyanide. Attacks some forms of plastic, rubber and coatings.
10.2 Chemical stability
Heat /contributes to instability/.
10.3 Possibility of hazardous reactions
Dangerous fire hazard when exposed to heat, flame or oxidizers.The vapour mixes well with air, explosive mixtures are easily formed.ACETONITRILE decomposes when heated to produce deadly toxic hydrogen cyanide gas and oxides of nitrogen. Strongly reactive [Hawley]. May react vigorously with strong oxidizing reagents, sulfuric acid, chlorosulfonic acid, sulfur trioxide, perchlorates, nitrating reagents, and nitric acid. [Sax, 9th ed., 1996, p. 20]. Potentially explosive in contact with nitrogen-fluorine compounds (e.g., tetrafluorourea) [Fraser, G. W. et al., Chem. Comm., 1966, p. 532].
10.4 Conditions to avoid
no data available
10.5 Incompatible materials
Strong oxidizers such as chlorine, bromine, and fluorine; chlorosulfonic acid; oleum or sulfuric acid. May accumulate static electricial charges, and may cause ignition of its vapors.
10.6 Hazardous decomposition products
When heated to decomposition, emits highly toxic fumes of /cyanides and nitrogen oxides/.
SECTION 11: Toxicological information
Acute toxicity
- Oral: LD50 - mouse (male) - 469 mg/kg bw.
- Inhalation: LC50 - mouse (male/female) - 3 587 ppm.
- Dermal: LD50 - rabbit (male/female) - > 2 000 mg/kg bw.
Skin corrosion/irritation
no data available
Serious eye damage/irritation
no data available
Respiratory or skin sensitization
no data available
Germ cell mutagenicity
no data available
Carcinogenicity
Weight-of-Evidence Characterization Under the current Risk Assessment Guidelines (US EPA, 1987), ACN is assigned carcinogen class D, not classifiable as to human carcinogenicity. There is an absence of human evidence and the animal evidence is equivocal. Under the Proposed Guidelines for Carcinogen Risk Assessment (US EPA, 1996), the carcinogenic potential of ACN following inhalation, oral, or dermal exposure is best characterized as "cannot be determined because the existing evidence is composed of conflicting data (e.g., some evidence is suggestive of carcinogenic effects, but other equally pertinent evidence does not confirm any concern)." Based on former classification guidelines
Reproductive toxicity
No information is available on the reproductive or developmental effects of acetonitrile in humans. (1-3) Animal studies appear to suggest that acetonitrile may cause developmental and reproductive effects such as a decrease in average fetal body weight and a significant increase in the number of malformed offspring. (1-3)
STOT-single exposure
The substance is irritating to the eyes. The substance may cause effects on the cellular respiration (inhibition). This may result in convulsions and respiratory failure. Exposure far above the OEL could cause death. The effects may be delayed. Medical observation is indicated.
STOT-repeated exposure
The substance may have effects on the blood. This may result in anaemia. The substance may have effects on the kidneys, liver and thyroid. This may result in impaired functions.
Aspiration hazard
A harmful contamination of the air can be reached rather quickly on evaporation of this substance at 20°C.
SECTION 12: Ecological information
12.1 Toxicity
- Toxicity to fish: LC50 - Pimephales promelas - 1 640 mg/L - 96 h.
- Toxicity to daphnia and other aquatic invertebrates: LC50 - Artemia salina - 641 mg/L - 24 h.
- Toxicity to algae: EC50 - Phaeodactylum tricornutum - 3 560 mg/L - 72 h.
- Toxicity to microorganisms: EC50 - activated sludge - > 1 000 mg l-1 - 30 min.
12.2 Persistence and degradability
AEROBIC: Enzyme-catalyzed hydrolysis of nitriles, such as acetonitrile, has been shown to proceed by two distinct routes(1,2); a nitrilase transforms the nitriles directly into acids plus ammonium ion, or a nitrile hydratase forms the amide which is hydrolyzed to acid plus ammonium ion by amidase(1,2). A mixed microbial culture isolated from an environment contaminated with organic cyanides and PCBs utilized acetonitrile as the sole source of carbon and nitrogen(3). The mixed microbial culture was grown for 48 hrs at pH 7 with 1 g/L of acetonitrile; the final pH and ammonia concentration were determined to be 8.81 and 80.1 umol/mL, respectively(3). The biodegradation studies of acetonitrile with mixed cultures of microorganisms from activated sludge and sewage show that degradation proceeds sluggishly without acclimatization of microorganisms, particularly at high concentration(4,5). Degradation is faster with acclimatization(6-11). With activated sludge as microbial inoculum, the lag period of acetonitrile degradation was about 1 day after which the compound degraded with a half-life of 1.2 days(8). Acclimated mixed microbial cultures isolated by an enrichment culture technique degraded 58% acetonitrile in 5 days(9). The biodegradability of acetonitrile was also observed with river water; the 12 day ThOD (theoretical oxygen demand) with river water was 40%(10,11). Acclimation of the microorganisms was examined by redosing; the degradation was 5 times faster after acclimation; it was also 4 times faster at 20 deg C than at 5 deg C(10,11). The biodegradation is expected to be much slower in seawater than in freshwater(12). Acetonitrile, present at 100 mg/L, reached 65% of its theoretical BOD in 4 weeks using an activated sludge inoculum at 30 mg/L in the Japanese MITI test which classified the compound as readily biodegradable(13).
12.3 Bioaccumulative potential
An estimated BCF of 3 was calculated in fish for acetonitrile(SRC), using a log Kow of -0.34(1) and a regression-derived equation(2). According to a classification scheme(3), this BCF suggests the potential for bioconcentration in aquatic organisms is low(SRC).
12.4 Mobility in soil
Acetonitrile has a reported measured Koc Value of 2.2(1). According to a classification scheme(2), this Koc value suggests that acetonitrile is expected to have very high mobility in soil(SRC).
12.5 Other adverse effects
no data available
SECTION 13: Disposal considerations
13.1 Disposal methods
Product
The material can be disposed of by removal to a licensed chemical destruction plant or by controlled incineration with flue gas scrubbing. Do not contaminate water, foodstuffs, feed or seed by storage or disposal. Do not discharge to sewer systems.
Contaminated packaging
Containers can be triply rinsed (or equivalent) and offered for recycling or reconditioning. Alternatively, the packaging can be punctured to make it unusable for other purposes and then be disposed of in a sanitary landfill. Controlled incineration with flue gas scrubbing is possible for combustible packaging materials.
SECTION 14: Transport information
14.1 UN Number
| ADR/RID: UN1648 (For reference only, please check.) | IMDG: UN1648 (For reference only, please check.) | IATA: UN1648 (For reference only, please check.) |
14.2 UN Proper Shipping Name
| ADR/RID: ACETONITRILE (For reference only, please check.) | IMDG: ACETONITRILE (For reference only, please check.) | IATA: ACETONITRILE (For reference only, please check.) |
14.3 Transport hazard class(es)
| ADR/RID: 3 (For reference only, please check.) | IMDG: 3 (For reference only, please check.) | IATA: 3 (For reference only, please check.) |
14.4 Packing group, if applicable
| ADR/RID: II (For reference only, please check.) | IMDG: II (For reference only, please check.) | IATA: II (For reference only, please check.) |
14.5 Environmental hazards
| ADR/RID: No | IMDG: No | IATA: No |
14.6 Special precautions for user
no data available
14.7 Transport in bulk according to IMO instruments
no data available
SECTION 15: Regulatory information
15.1 Safety, health and environmental regulations specific for the product in question
| Chemical name | Common names and synonyms | CAS number | EC number |
|---|---|---|---|
| Acetonitrile | Acetonitrile | 75-05-8 | 200-835-2 |
| European Inventory of Existing Commercial Chemical Substances (EINECS) | Listed. | ||
| EC Inventory | Listed. | ||
| United States Toxic Substances Control Act (TSCA) Inventory | Listed. | ||
| China Catalog of Hazardous chemicals 2015 | Listed. | ||
| New Zealand Inventory of Chemicals (NZIoC) | Listed. | ||
| Philippines Inventory of Chemicals and Chemical Substances (PICCS) | Listed. | ||
| Vietnam National Chemical Inventory | Listed. | ||
| Chinese Chemical Inventory of Existing Chemical Substances (China IECSC) | Listed. | ||
| Korea Existing Chemicals List (KECL) | Listed. | ||
SECTION 16: Other information
Information on revision
| Creation Date | July 15, 2019 |
|---|---|
| Revision Date | July 15, 2019 |
Abbreviations and acronyms
- CAS: Chemical Abstracts Service
- ADR: European Agreement concerning the International Carriage of Dangerous Goods by Road
- RID: Regulation concerning the International Carriage of Dangerous Goods by Rail
- IMDG: International Maritime Dangerous Goods
- IATA: International Air Transportation Association
- TWA: Time Weighted Average
- STEL: Short term exposure limit
- LC50: Lethal Concentration 50%
- LD50: Lethal Dose 50%
- EC50: Effective Concentration 50%
References
- IPCS - The International Chemical Safety Cards (ICSC), website: http://www.ilo.org/dyn/icsc/showcard.home
- HSDB - Hazardous Substances Data Bank, website: https://toxnet.nlm.nih.gov/newtoxnet/hsdb.htm
- IARC - International Agency for Research on Cancer, website: http://www.iarc.fr/
- eChemPortal - The Global Portal to Information on Chemical Substances by OECD, website: http://www.echemportal.org/echemportal/index?pageID=0&request_locale=en
- CAMEO Chemicals, website: http://cameochemicals.noaa.gov/search/simple
- ChemIDplus, website: http://chem.sis.nlm.nih.gov/chemidplus/chemidlite.jsp
- ERG - Emergency Response Guidebook by U.S. Department of Transportation, website: http://www.phmsa.dot.gov/hazmat/library/erg
- Germany GESTIS-database on hazard substance, website: http://www.dguv.de/ifa/gestis/gestis-stoffdatenbank/index-2.jsp
- ECHA - European Chemicals Agency, website: https://echa.europa.eu/
Other Information
Specific treatment is necessary in case of poisoning with this substance; the appropriate means with instructions must be available.Oxygen should be administered exclusively by specially trained first aid or medical personnel.Do NOT take working clothes home.
Any questions regarding this SDS, Please send your inquiry to sds@xixisys.com
Disclaimer: The above information is believed to be correct but does not purport to be all inclusive and shall be used only as a guide. The information in this document is based on the present state of our knowledge and is applicable to the product with regard to appropriate safety precautions. It does not represent any guarantee of the properties of the product. We as supplier shall not be held liable for any damage resulting from handling or from contact with the above product.